| ORIGINAL RESEARCH |
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| Year : 2019 | Volume
: 8
| Issue : 4 | Page : 158-166 |
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Lipoprotein heterogeneity at birth and its relationship with gestational age, gender and birth weight: A cross-sectional study from a rural teaching Hospital of Central India
Smita Priyadarshan Jategaonkar1, Kanchan Gawde2, Manish Jain3
1 MD (Pediatrics), DNB (Pediatrics), DCH, PGDND; Assistant Professor, Department of Pediatrics; Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha- 442102, Maharashtra, India
2 MD (Pediatrics), MBBS; Senior Resident, Department of Pediatrics; Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha- 442102, Maharashtra, India
3 MD (Pediatrics); Professor and Head; Department of Pediatrics; Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha- 442102, Maharashtra, India
Correspondence Address:
Smita Priyadarshan Jategaonkar
403, Royal Heritage, Shriniwas Colony, Ramnagar, Wardha, Maharashtra - 442 102
India
 Source of Support: None, Conflict of Interest: None
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Introduction: Intra-uterine fetal metabolic aberrations produce several life-threatening ailments in adult life, including atherosclerotic disease. In that context, though lipid profile has been extensively studied in adults as an excellent marker of the cardiovascular status, similar studies involving pediatric population are largely lacking, especially on umbilical cord-blood.
Aims and Objectives: The aim of the present paper is to improve upon the existing knowledge about cord-blood lipid profile in newborns and its correlation with gestational age, gender and birth-weight in newborns.
Materials and Methods: This is a hospital-based cross- sectional study involving 105 neonates born at a rural tertiary- care teaching hospital of central India for the calendar year 2015. Umbilical cord-blood samples of all these newborns were biochemically assessed and statistically analyzed for various parameters of lipid profile, including apolipoproteins
Results: Small-for-gestational-age neonates had markedly significant higher levels of all the lipid panel values. Amongst them, female neonates had slightly higher readings than their male counterparts, though the variations did not reach statistical significance. However, the difference of Atherogenic Index between small (4.24± 16.67) and appropriate (1.59±1.39) for gestational age neonates was not statistically significant.
Discussion: Findings in our study were discussed in the light of the present-day literature to arrive at clinically valuable implications.
Conclusion: Cord-blood lipid screening provides an opportunity to identify and treat high risk neonates, like the small-for-gestational-age, for prevention of impending coronary artery disease in their adult lives.
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