• Users Online: 167
  • Print this page
  • Email this page
ORIGINAL RESEARCH
Year : 2020  |  Volume : 9  |  Issue : 4  |  Page : 151-156

Changing serotypes of rotavirus in Western India and clinical severity of diarrhoea


1 Department of Medical Genetics & Biotechnology, MGMIHS, Kamothe, Navi Mumbai, Maharashtra, India
2 Department of Pediatrics, MGM Medical College and Hospital, Navi Mumbai, Maharashtra, India

Correspondence Address:
Nimain Mohanty
Department of Pediatrics, MGM Medical College, Navi Mumbai, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpai.jpai_6_21

Rights and Permissions

Introduction: Rotavirus and Norovirus diarrhea pose highest threat to neonates and toddlers all over the world. Diarrhoea happens to be the second most common cause of under-5 mortality in India after Pneumonia. India has the highest incidence of rotavirus diarrhoea, contributing to about 1,50,000 inder-5 deaths annually. Virus serotypes do undergo constant changes, varying in different regions, thought of responding to vaccines differently. Objecive: A prospective observational study was undertaken in Kamothe, Navimumbai (India); enlisting 207 cases of acute watery diarrhoea among under-5 children to study incidence of Rotavirus and Norovirus as causal agents and their serotypes. Efforts were made to understand if virus positivity and their types were related to clinical severity of diarrhoea. Method: Stool samples were collected and tested for rotavirus and norovirus from cases of acte diarrhoea on clinical presentation and after excluding cases of dysentery on clinical presentation. 10.62% cases were found positive for rotavirus RNA by ELISA and 4.83% by Electropherotyping. Cases of acute watery diarrhoea having rotavirus positive and negative stool showed remarkable difference with diarrhoea severity assessed by Vesikary scores. Severe dehydration, stool frequency, vomiting and weight loss were associated with rotavirus infection in younger age group. Long electropherotypes were more prevalent (86.36%) and were associated with higher clinical severity of diarrhoea. P[8] was predominant (77.27%) followed by P[4] (13.63%) genotypes. Neither P[6] nor P[11] was detected. Those found positive for rotavirus in their stool samples, were negative in their serum by eletropherotyping. Only 0.48% of diarrhoea stool samples were found positive for Norovirus by ELISA. Conclusion: Rotavirus diarrhoes shown a decreasing trend in Navimumbai area as compared to previous years. Incidence of Norovirus infection was found very low. Rotavirus positive cases, particularly of long arm electropherotypes, showed clinical severity of diarrhoea as compared to short-arm types and in those found negative for rotavirus or Norovirus.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed199    
    Printed10    
    Emailed0    
    PDF Downloaded17    
    Comments [Add]    

Recommend this journal