Background: High prevalence of goiter is regarded a public health problem due to iodine deficiency disorder (IDD). Goiter in spite of urinary iodine sufficiency is also being reported. Even though. Universal iodization of salt (UIS) is mandatory in our country; sale of non iodized salt is still prevailing. Objective: To estimate the presence of goiter, mean urinary iodine excretion (UIE) level among prepubertal school children and also adequacy of salt iodization. Methods: 400 prepubertal school children were screened for goiter, UIE was estimated on every 10th child and 30 salt samples were tested for optimum iodization. Results: There was a high incidence of goiter in 112 (28%); Grade 1 Goiter-14.75% and Grade 2-13.25%. Mean UIE was 115 ug/L with no samples having <100 ug/L indicating current iodine sufficiency. Among the 30 salt samples tested, 26 (86 %) were optimally iodized, 2 (7%) were suboptimally iodized and 2 (7%) were found to have no trace of iodine, even though all were labelled as iodized salt. Conclusion: Goiter is a public health problem in the study area, but current iodine sufficiency is noted as per UIE. This paradox can be explained by the transition phase during shift from iodine deficiency to iodine sufficiency or may be the result of other confounders. Goiter due to previous iodine deficiency may take several years to resolve. Inadequately iodized salt is still being marketed, getting transported by roadways. Recommendation: There is a need for reappraisal of goiter, UIE and adequacy of salt iodization. Further research on other causes of goiter like consumption of goitrogens and reduced response of iodine due to opposing action by excess fluorine and cobalt and associated iron deficiency is recommended.

Ichthyosis is a very heterogeneous family of skin disorders with harlequin ichthyosis being the most severe genetic form. It is a rare autosomal recessive condition, characterized by dry, severely thickened skin with large plates of hyperkeratotic scale, separated by deep fissures. Infants are very susceptible to metabolic abnormalities and infections. They usually do not survive for very long, but several long term survivals have been noted. The vast majority of affected individuals are homozygous for mutations in the ABCA12 gene, which cause a deficiency of the epidermal lipid transporter, resulting in hyperkeratosis and abnormal barrier function. We report a case of a newborn with harlequin ichthyosis, born to unrelated parents, who had a favorable evolution but later on died unfortunately.

The chromosomal segment 12p13 harboring ETV6 or TEL gene plays a pivotal role in leukemogenesis of childhood acute lymphoid leukemia (ALL) of B-lineage. The plethora of fusion of ETV6 with RUNX1 in 21q22 has led to understand the disease mechanism and prognosis of the ALL-subgroup. Although 12p13 partners rearrangement with any other chromosomes, their entity is limited in the literature. We present the first Indian case, most likely the second global case, with double monosomy of 9 and 12 in a 9 year old girl along with information available in this relevance.

Idiopathic infantile myelofibrosis an uncommon haematological condition characterized by progressive fibrous tissue replacement of bone marrow. Its incidence is 0.5-1 in 100000 population. Patient manifests with hepatosplenomegaly which is a typical finding. Diagnosis is confirmed by bone marrow biopsy. We report a case of 5 year old female child with unexplained spleno-hepatomegaly & diagnostic features on bone marrow biopsy who is currently on prednisolone treatment & is showing response to it.